OP06.05: Differences in pulmonary reactivity between healthy and growth‐restricted fetuses estimated by means of computational modelling

The aim of this study was to quantify dynamic changes in the properties fetal pulmonary circulation induced by maternal hyperoxygenation (MHO) fetuses with growth restriction (FGR) means a simplified computational model. Doppler images from RVOT, intra-pulmonary artery (IPA) and ductus arteriosus (DA), together valve diameter (PVd), were obtained under normoxia MHO conditions pregnant women. Normoxia acquired while mother breathing room air. Then, 100% O2 administered via non-rebreather face mask during 10 min. Images after min keeping same conditions. A model constructed (figure A). parameters personalised using 3 velocity waveforms, PVd, EFW GA every subject, estimate systemic resistances both MHO. total 22 (GA = 32.7 ± 2.8 weeks; 2088 528 g) controls 16 FGR 33.3 3.5 1752 584 analysed. IPA velocities significantly reduced compared B, C) as consequence higher lung resistance. However, show significant decreased resistance MHO, also demonstrated increased C). Our results suggested that baseline is it can be reversed do not change On contrary, there seems no difference reactivity circulation. Please note: publisher responsible for content or functionality any supporting information supplied authors. Any queries (other than missing content) should directed corresponding author article.